Tuesday, July 24, 2012

Saints LB Jonathan Vilma, NFL lawyers in court

New Orleans Saints linebacker Jonathan Vilma arrives at federal court in New Orleans, Monday July 23, 2012. Vilma and lawyers for the NFL arrived at federal court for a settlement conference in Vilma's lawsuit seeking to overturn his season-long suspension in the Saints bounty investigation. (AP Photo/The Times Picayune, Ted Jackson)NO SALES, MAGS OUT NO SALES, MAGS OUT

New Orleans Saints linebacker Jonathan Vilma arrives at federal court in New Orleans, Monday July 23, 2012. Vilma and lawyers for the NFL arrived at federal court for a settlement conference in Vilma's lawsuit seeking to overturn his season-long suspension in the Saints bounty investigation. (AP Photo/The Times Picayune, Ted Jackson)NO SALES, MAGS OUT NO SALES, MAGS OUT

New Orleans Saints linebacker Jonathan Vilma arrives at federal court in New Orleans, Monday July 23, 2012. Vilma and lawyers for the NFL arrived at federal court for a settlement conference in Vilma's lawsuit seeking to overturn his season-long suspension in the Saints bounty investigation. At right is attorney Peter Ginsberg. Man at left is unidentified. (AP Photo/The Times Picayune, Ted Jackson)NO SALES, MAGS OUT NO SALES, MAGS OUT

National Football League Commissioner Roger Goodell at the Allen & Company Sun Valley Conference in Sun Valley, Idaho, Thursday, July 12, 2012. (AP Photo/Paul Sakuma)

Attorneys representing the NFL, from left, Lynn Swanson, Gladstone N. Jones, III and Gregg Levy arrive at federal court in New Orleans, Monday, July 23, 2012. New Orleans Saints linebacker Jonathan Vilma and lawyers for the NFL arrived at federal court Monday for a settlement conference in Vilma's lawsuit seeking to overturn his season-long suspension in the Saints bounty investigation. (AP Photo/The Times Picayune, Ted Jackson)NO SALES, MAGS OUT NO SALES, MAGS OUT

ADVANCE FOR WEEKEND OF JULY 21-22 - FILE - In this Oct. 16, 2011, file photo, New Orleans Saints linebacker Jonathan Vilma (51) takes down Tampa Bay Buccaneers running back Kregg Lumpkin (28) during the second quarter of an NFL football game in Tampa, Fla. Vilma is suspended for the 2012 season for his role in the bounty program an NFL investigation unveiled. (AP Photo/Brian Blanco, File)

(AP) ? Saints linebacker Jonathan Vilma and defensive end Will Smith met Monday with NFL lawyers and a federal magistrate in a settlement conference for lawsuits spawned by the players' suspensions following the league's bounty investigation.

Vilma and his attorneys emerged from the three-hour-long conference with U.S. Magistrate Daniel Knowles III without commenting on whether progress was made toward resolution of the case. The meeting was closed to the public.

Peter Ginsberg, one of Vilma's attorneys, said only that the group "went through the settlement process" and that he expects "things will move along."

Vilma declined to comment on the talks, but said, "I want the team to do well, and I want to be part of the team."

The star linebacker and Saints coach Sean Payton have been suspended for the 2012 season for their alleged roles in a bounty program the NFL says targeted opposition players for three seasons. Smith is suspended for four games.

NFL attorneys and lawyers for Smith also declined comment.

Vilma's lawsuit claims NFL Commissioner Roger Goodell failed to make a timely appeal ruling regarding his season-long suspension.

His suit also asks for a temporary restraining order to allow Vilma to rejoin the team. U.S. District Judge Helen Berrigan in New Orleans is scheduled to hold a hearing Thursday on that request.

Vilma filed a separate suit against Goodell for alleged defamation of character. The NFL Players Association sued the NFL on behalf of Smith and two other suspended players, Scott Fujita and Anthony Hargrove.

The Saints open training camp on Tuesday.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-07-23-Bounties-Vilma/id-75e982d11d4f462eb9611a278dd05987

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Study offers new clue on how brain processes visual information

Monday, July 23, 2012

Ever wonder how the human brain, which is constantly bombarded with millions of pieces of visual information, can filter out what's unimportant and focus on what's most useful?

The process is known as selective attention and scientists have long debated how it works. But now, researchers at Wake Forest Baptist Medical Center have discovered an important clue. Evidence from an animal study, published in the July 22 online edition of the journal Nature Neuroscience, shows that the prefrontal cortex is involved in a previously unknown way.

Two types of attention are utilized in the selective attention process ? bottom up and top down. Bottom-up attention is automatically guided to images that stand out from a background by virtue of color, shape or motion, such as a billboard on a highway. Top-down attention occurs when one's focus is consciously shifted to look for a known target in a visual scene, as when searching for a relative in a crowd.

Traditionally, scientists have believed that separate areas of the brain controlled these two processes, with bottom-up attention occurring in the posterior parietal cortex and top-down attention occurring in the prefrontal cortex.

"Our findings provide insights on the neural mechanisms behind the guidance of attention," said Christos Constantinidis, Ph.D., associate professor of neurobiology and anatomy at Wake Forest Baptist and senior author of the study. "This has implications for conditions such as attention deficit hyperactivity disorder (ADHD), which affects millions of people worldwide. People with ADHD have difficulty filtering information and focusing attention. Our findings suggest that both the ability to focus attention intentionally and shifting attention to eye-catching but sometimes unimportant stimuli depend on the prefrontal cortex."

In the Wake Forest Baptist study, two monkeys were trained to detect images on a computer screen while activity in both areas of the brain was recorded. The visual display was designed to let one image "pop out" due to its color difference from the background, such as a red circle surrounded by green. To trigger bottom-up attention, neither the identity nor the location of the pop-out image could be predicted before it appeared. The monkeys indicated that they detected the pop-out image by pushing a lever.

The neural activity associated with identifying the pop-out images occurred in the prefrontal cortex at the same time as in the posterior parietal cortex. This unexpected finding indicates early involvement of the prefrontal cortex in bottom-up attention, in addition to its known role in top-down attention, and provides new insights into the neural mechanisms of attention.

"We hope that our findings will guide future work targeting attention deficits," Constantinidis said.

###

Wake Forest Baptist Medical Center: http://www.wfubmc.edu

Thanks to Wake Forest Baptist Medical Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/121922/Study_offers_new_clue_on_how_brain_processes_visual_information

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Ten great reasons for writers to visit Fantasycon

FantasyConIn case you haven?t yet come across FantasyCon, it?s the fabulous annual meet-up for writers, editors, artists, publishers, and anyone else connected with the fantasy and horror genres, organised by the British Fantasy Society. The 2012 event is taking place from September 27 to 30, and it?s all going on in Brighton, England, at the Royal Albion Hotel. Here?s a round-up of just some of the reasons to be there.

1. Special Media Guests

The latest news on special media guests at the con is that Robin Hardy is coming along to introduce a special screening of his film The Wicker Tree, which reprises the territory and themes of his famous classic, The Wicker Man. And if that weren?t enough, Mark Gatiss will be making an appearance ? the actor, screenwriter, author of the wonderful Lucifer Box novels and of course the co-creator of The League of Gentlemen and Sherlock TV series. OK, I?m slightly giddy now . . .

2. Guests of Honour

Attendees at the con will also be able to hear from the guests of honour, including Texan writer Joe R. Lansdale, author of over thirty novels; Mary Danby, editor of thirteen volumes of The Fontana Book of Great Horror Stories; New York Times best-selling fantasy writer Brent Weeks; and TV presenter and horror writer Muriel Grey. Events will be rounded up in style by master of ceremonies Tim Lebbon, award-winning author of Fallen, Coldbrook, Dusk and Echo City, among other titles.

3. Talks, interviews, panels, presentations

Between meeting other con-goers and visits to the bar, there is always a great programme of events at FantasyCon. Besides appearances by the guests of honour there will be panel discussions on genre writing and publishing, inside views from industry specialists, tips from agents and publishers, invaluable ?been-there? advice from established practitioners, practical insights on surviving the writing life without losing your marbles, insightful interviews with authors from across the world, and masterclasses to help develop new skills.

4. The bar

Here?s the place to catch up with old friends and meet new ones. I remember being quite nervous when I attended my first FantasyCon, but found it wonderfully friendly ? it really is a great place to meet like-minded people over a glass of your favourite tipple. If you?re shy and this is your first con, there is even a special area where you can meet other newcomers and indeed someone who will show you around. On a more serious note, it?s a good place to network and make connections with people in genre publishing. One of the best aspects of attending, though, is simply meeting some lovely people and making friends for life. A lot of people I?ve met at the event describe the FantasyCon crowd as being like a family . . . really, there?s nothing to fear! Unless of course . . .

5. Readings

. . . you go along to some of the atmospheric readings. Last year these took place either in Bar Rogue or in a moodily lit room upstairs. Listen to some spooky ghost stories, fantastical tales or extracts from novels. The roster is yet to be announced but last year had some wonderful offerings from the likes of Rob Shearman, John L. Probert, Simon Bestwick and many others. And if you want to share your work and polish your reading skills in a friendly environment, at the time of writing, there is still time to volunteer to give a reading too.

6. Sit back and be entertained

The full programme of events will be announced closer to the date, but if last year?s roster is anything to go by, no one will be short of things to do! With film showings, a disco, staged entertainment including a his-and-hers burlesque show and hilarious pantomimes put on by Teatro Proberto, it was an absolute riot . . . and that?s all without venturing outside the hotel. Don?t forget to get your hands on some raffle tickets and try to win some fab prizes, including signed books, limited editions, proof copies and artwork.

7. The dealer room and art show

The dealer room at FantasyCon is a veritable treasure chest ? I shall be bringing along a spare and rather sturdy bag in case I can?t resist. Apparently the dealer space is already sold out for 2012, so there will be another good turnout.? Publishers coming along include PS Publishing, Chomu, TTA Press, Eibonvale, Angry Robot and Screaming Dreams, to name a few. There are usually some rather nice finds in the event goodie bags as well. Yes, all this and freebies too! Last year there was also an art show alongside the event, where genre illustrators and artists can show their work and have prints and originals for sale.

8. Book Launches

Okay, here?s where you?ll need another sturdy bag. In the main bar, and sometimes spilling out into other areas of the con, there will be a whole series of signing and book launch events. Some of the books on offer will be special pre-release items, including the Mammoth Book of Ghost Stories by Women and the Mammoth Book of Best New Horror. Have your copies signed by many of the contributors ? some of these events also have a free glass of wine on offer when you buy a book.

I believe more launches are being added to the schedule, but you can see the ones timetabled so far ? FantasyCon launches 2012.

9. Awards banquet

Enjoy a banquet at the British Fantasy Awards ceremony, the grand finale of FantasyCon. This year?s longlist has been voted on by members of the BFS and overseen by special juries . . . find out who wins at this event on the Sunday afternoon of the con. Check out the BFS nominees and decide on your favourites.

10. A trip to the seaside

If you get chance to emerge from the hotel and go blinking into the daylight, beyond the event lies all of Brighton. The famous beach and pier are straight opposite the venue ? there?s even a log flume to clear the morning hangover, while fans of a good scare (or just a bit of a giggle) can make a trip to the Horror Hotel. If you wish to explore further, there?s plenty to see ? shopping in The Lanes, the Royal Pavilion, Brighton wheel and plenty of restaurants, not to mention a paddle and an ice cream.

11. (Bonus!) Erm, did I mention the bar . . . ?

?

Further information about FantasyCon 2012 including details of how to join.

ALISON LITTLEWOOD

?

Alison LittlewoodAlison?s first novel, A Cold Season, is out now from Jo Fletcher Books, an imprint of Quercus. It was a Richard and Judy Book Club pick for spring 2012.
Facebook: Alison Littlewood Facebook
Twitter:
?@Ali__L
Website: Alison Littlewood

Source: http://www.armedwithpens.com/ten-great-reasons-for-writers-to-visit-fantasycon/

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Monday, July 23, 2012

Barry Larkin, Ron Santo inducted into Hall of Fame | Baseball Notebook

COOPERSTOWN, N.Y. ? Barry Larkin lost it before he even started. Vicki Santo never wavered as she honored her late husband, Ron.

Larkin, the former star shortstop for the Cincinnati Reds, and Ron Santo, a standout third baseman for the Chicago Cubs and later a beloved broadcaster for the team, were inducted into the Baseball Hall of Fame on Sunday.

After wiping away tears as his teenage daughter sang the national anthem, Larkin quickly thanked his mom, Shirley, and father, Robert, who were seated in the first row.

"Growing up, you challenged me. That was so instrumental," Larkin said.

Larkin heaped special praise on former player-manager Pete Rose, a fellow Cincinnati native who is ineligible for the Hall of Fame.

"I wouldn't be in the big leagues if it weren't for Pete," Larkin said, to rousing applause from fans.

Larkin, who played his entire 19-year career with the Reds, retired after the 2004 season with a .295 career average, 2,340 hits, 1,329 runs scored and 379 stolen bases.

Seattle native Ron Santo didn't live to experience the day he always dreamed of. Plagued by health problems, he died Dec. 3, 2010, at age 70. His long battle with diabetes cost him both legs below the knees, but he ultimately died of complications from bladder cancer.

A member of the Chicago Cubs organization for the better part of five decades as a player (1960-74) and then beloved broadcaster (1990-2010), Santo was selected by the Veterans Committee in December, exactly one year after his death.

Vicki Santo said she cried a lot while practicing her speech, but her poise was remarkable.

"It just feels right, a perfect ending to a remarkable journey," she said. "This is not a sad day. This is a great day. I'm certain that Ronnie is celebrating right now."

So, too were his beloved Cubs. They paid a tribute of their own to Santo, clicking their heels as they jumped over the third-base line to start the bottom of the first inning at St. Louis.

In 15 major league seasons, all but one with the Cubs, Santo was one of the top third basemen in major league history. He compiled a .277 batting average, had 2,254 hits, 1,331 RBI and 365 doubles in 2,243 games. He also was a tireless fundraiser for juvenile diabetes, raising more than $65 million.

Santo fought serious medical problems after he retired as a player. He underwent surgery on his eyes, heart and bladder after doctors discovered cancer. He also had surgery more than a dozen times on his legs before they were amputated below the knees ? the right one in 2001 and the left a year later.

As a broadcaster, Santo was known for unabashedly rooting for the Cubs, a trait that endeared him to fans who never saw him play.

"I want you to know that he loved you so much, and he would be grateful that you came here to share this with him," Vicki Santo said to the fans. "He fought the good fight, and though he's no longer here we need to find a cure (for juvenile diabetes). He felt he had been put here for that reason. He believed in his journey. He believed in his cause. We can't let him down."

Notes

? Roberto Hernandez publicly apologized to Cleveland teammates for deceiving them. The former All-Star pitcher, then known as Fausto Carmona, pretended to be somebody else for 12 years. He can rejoin the team after serving a three-week suspension.

? Detroit's Miguel Cabrera became only the second Venezuelan-born player with 300 career homers when he hit two against the White Sox. Andres Galarraga hit 399.

? OF Carlos Quentin agreed to a $27 million, three-year contract with the Padres that includes a no-trade clause.

Source: http://feeds.seattletimes.com/click.phdo?i=74f7396d73a7be8bf54dc31212b2d27c

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Refresh Roundup: week of July 16th, 2012

Refresh Roundup week of July 16th, 2012

Your smartphone and / or tablet is just begging for an update. From time to time, these mobile devices are blessed with maintenance refreshes, bug fixes, custom ROMs and anything in between, and so many of them are floating around that it's easy for a sizable chunk to get lost in the mix. To make sure they don't escape without notice, we've gathered every possible update, hack, and other miscellaneous tomfoolery we could find during the last week and crammed them into one convenient roundup. If you find something available for your device, please give us a shout at tips at engadget dawt com and let us know. Enjoy!

Continue reading Refresh Roundup: week of July 16th, 2012

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Refresh Roundup: week of July 16th, 2012 originally appeared on Engadget on Sun, 22 Jul 2012 21:16:00 EDT. Please see our terms for use of feeds.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/U6KKqxq_VOs/

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Netanyahu: Israel will do 'whatever is necessary' to protect Israelis from terrorist attacks

[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

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Source: http://news.yahoo.com/netanyahu-israel-whatever-necessary-protect-israelis-terrorist-attacks-153012182.html

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Sunday, July 22, 2012

HBT: Cain, Hamels homer off each other? | ?SF wins

Here?s something pretty cool.

Matt Cain launched a solo home run off opposing pitcher Cole Hamels in the top of the third inning this afternoon in Philadelphia. Not to be outdone, Hamels connected for a solo shot of his own off Cain in the bottom of the inning. No word on whether Hamels was whistling ?Anything You Can Do? during his home run trot, but it can?t be ruled out.

Cain and Hamels are the first pitchers to homer off each other in the same game since Kevin Millwood and Denny Stark on May 18, 2002. Per ESPN?s Jayson Stark, they are the first pitchers to homer off each other in the same inning since Kevin Gross and Fernando Valenzuela did it on May 14, 1990.

There?s a chance Cain and Hamels could have more in common soon, as Jon Heyman of CBSSports.com reports that the Phillies and Hamels are ?moving in the right direction? in negotiations on a long-term contract extension. Cain?s $127.5 million commitment with the Giants is considered a starting point on negotiations for Hamels.

Source: http://hardballtalk.nbcsports.com/2012/07/21/cole-hamels-and-matt-cain-homer-off-each-other-in-the-same-inning/related/

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Saturday, July 21, 2012

4 Truths You Probably Don't Know About Limo Service | Absolute ...

CT Limo ServiceLimo service is fraught with misconceptions?They?re expensive, hard to find, can only be rented for large blocks of time, are reserved for celebrities and the list goes on. We are here to dispel those myths and set the record straight.

1. Myth: Limo Service is Overpriced
Fact: On a per passenger basis, with a full vehicle of passengers, a limo is a far better deal than a sedan (almost 1/3 less per passenger). Additionally, when compared to the tangible and emotional costs of a DWI/DUI, limousine service is far and away a better deal.

2. Myth: Limousines are Only for Celebrities and the Uber Rich
Fact: While we do not check tax returns on our customers, or ask for a statement of net worth, we are fairly confident in the statement that the majority of our customers rarely fit into the aforementioned buckets. That being said, even if they did, we?re not going to divulge that information in the interest of protecting the privacy and identities of our passengers.

3. Myth: Limousines are not Environmentally Friendly
Fact: According to a leading coach builder, Royale, Lincoln and Cadillac stretch limousines are twice as efficient, on a per passenger basis, than a chauffeured Prius sedan. In Connecticut, a 120? limo (which was used in this calculation) is the largest limo that can legally be registered and rented.

4. Myth: Limos can only be booked in large blocks of time.
Fact: Rental terms and conditions are set by the limo company providing service. Airport limo trips as well as pick-up and drop-off service can often be arranged, if planned well in advance.

While we are sure there are other myths out there, these are some of the most common comments we receive from prospective passengers and customers. Do you have any questions about limo service?we can help with? If so, feel free to comment below!

Source: http://www.absolute-transportation.com/blog/2012/07/19/4-truths-you-probably-dnt-know-about-limo-service/

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ECB's Draghi: euro not in danger

FILE - In this July 5, 2012 file photo President of the European Central Bank Mario Draghi speaks during a news conference in Frankfurt, central Germany. Draghi said in an interview with French daily Le Monde posted on the bank's website Saturday, July 21, 2012, that predictions of a eurozone "explosion" underestimate "the political capital that our leaders have invested in this union, as well as the support of European citizens." (AP Photo/dapd, Mario Vedder, File)

FILE - In this July 5, 2012 file photo President of the European Central Bank Mario Draghi speaks during a news conference in Frankfurt, central Germany. Draghi said in an interview with French daily Le Monde posted on the bank's website Saturday, July 21, 2012, that predictions of a eurozone "explosion" underestimate "the political capital that our leaders have invested in this union, as well as the support of European citizens." (AP Photo/dapd, Mario Vedder, File)

FILE - In this July 5, 2012 file photo President of the European Central Bank Mario Draghi speaks during a news conference in Frankfurt, central Germany. Draghi said in an interview with French daily Le Monde posted on the bank's website Saturday, July 21, 2012, that predictions of a eurozone "explosion" underestimate "the political capital that our leaders have invested in this union, as well as the support of European citizens." (AP Photo/dapd, Mario Vedder, File)

BERLIN (AP) ? The head of the European Central Bank said the euro is "absolutely not" in danger as the continent's financial crisis simmers, and insisted in an interview published Saturday that the multi-nation currency is "irrevocable."

Worries about the 17-nation eurozone's future health have been fueled lately by Greece's persistent troubles and by the financial woes of Spain, the bloc's fourth-biggest economy. European ministers this week signed a rescue package worth up to ?100 billion ($122 billion) for its ailing banks, but concern flared about Spain's prolonged recession and the debts of its regions, and the country's borrowing costs rose.

Asked in an interview with French daily Le Monde whether the euro is in danger, ECB President Mario Draghi replied: "No, absolutely not."

When outside analysts draw up scenarios for an "explosion" of the eurozone, "that underestimates the political capital that our leaders have invested in this union, as well as the support of European citizens," Draghi said in the interview, which was posted on the ECB's website.

"The euro is irrevocable," he added.

The ECB this month cut its benchmark interest rate to a record-low 0.75 percent but gave little sign of further action soon to ease the crisis. It already has made two rounds of three-year emergency loans to banks, but has shown little appetite to reactivate its government bond-buying program.

"Our mandate is not to resolve the financial problems of countries, but to ensure price stability and to contribute to the stability of the financial system in full independence," Draghi said in the interview with Le Monde, conducted Wednesday ? emphasizing the ECB's primary task of fighting inflation.

Asked whether the ECB should do more to ease the economy, Draghi replied: "We are very open. We do not have any taboos."

He said the ECB decided to cut interest rates in July because it forecast that inflation would be at its target level ? close to or below 2 percent ? at the start of 2013.

"It now seems likely that it will fall sooner than expected, at the end of 2012," he said. "Our mandate is to maintain price stability in order to prevent both higher inflation and a generalized, broadly based fall in prices. If we see such risks of deflation, we will act."

As for the eurozone economy, Draghi said that the situation "has gradually worsened, but not to the point of plunging the whole of the monetary union into recession."

"We still expect a very gradual improvement in the situation by the end of this year or the beginning of next year," he said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-07-21-European%20Central%20Bank/id-4e5eb8b4053d450382a10f1ad1763b06

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Milwaukee Avenue Arts Fest Kicks Off | NBC Chicago

clipart.com

Three stages of music will keep the entertainment flowing at the Milwaukee Avenue Arts Fest.

Summer in Chicago is filled with street fests and outdoor activities, but no summer is complete without the annual event known as the Milwaukee Avenue Arts Festival.

From July 20-22, the streets of Logan Square will be transformed into a outdoor mecca of arts and entertainment.

More than 100 artists will be displaying their work and handmade goods, three stages of live music will be set up and there'll be a plethora of activities for kids and adults.

Belly up to the gourmet food trucks, sip some ice-cold sangria and take some photos you?ll probably regret in the photo booth.

The suggested donation is $5, or you can purchase a three-day festival band to get admission for the whole fest for only $10.

After all, summer is short. Live it up while it lasts.

Source: http://www.nbcchicago.com/news/local/Milwaukee-Avenue-Arts-Fest-163095136.html

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Friday, July 20, 2012

Video: US Stocks Rally

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Source: http://video.msnbc.msn.com/cnbc/48246980/

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Loan For Auto: Online car insurance service

When trying to get the online car insurance service, people will naturally choose the kinds of protection that could give more coverage with less payment. Of course, there is nothing wrong in hoping for this, in fact, you and all of the other people could really get one of such best insurance if you want to spare some effort into it.?

What you first need is to find the kind of site which could help you giving all the information you need about car insurance. Though such a site may be easy to find, but this is not everything you need still. The site in question should also be able to give you more details about auto insurance rates or interests you have to pay in tandem with your main insurance later. If possible, look into the site for the kind of calculator program (usually called as the insurance aggregator) you can use to simulate the future condition of your insurance payment. Apart from the regular tips and tricks in buying auto insurance, this program could really save not just your money, but also your overall financial budget over the years to come when you finally start paying for your auto insurance later on.

Source: http://heatherfishstudio.blogspot.com/2012/07/online-car-insurance-service.html

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Suggestions For Simpler Training Your Dog - Free Pets to Good Home

A frequent family pet between many people are pet dogs. Pet dogs are actually excellent family companions, since they are really adorable and fun. Dogs can be a excellent dog for anybody when they are skilled effectively. Use the suggestions in the following article if you want aid training your puppy.

The ideal tip anyone can offer with regards to puppy training is function as the alpha. Canines are seeking their human experts being the rest director. In any way cost screen assurance, firmness, and you should not, less than any circumstances prove to them weakness. They normally desire to follow a robust director, so make sure that you present yourself consequently.

To make education your puppy efficient, stay away from attempting to train it when you?re mad at it. When you are annoyed, there is no method for you to give acceptable requests in your pet, as you will allow all your other worries take over any rational opinions. For that reason, you must hold out until you have calmed downward before attempting to workout your pet dog.

Never ever punish your puppy, or discipline him, once the simple fact. In the event that he urinated about the carpet previously from the time, penalizing him now won?t support. Canines are unable to explanation and possess quite short-term remembrances, so that they will not connect the earlier accident using the penalties accessible.

Stop your dog from bouncing to you by not giving him optimistic interest when he does so. A great deal of canines jump because they are seeking that attention. If you get to out and family pet them, even while you chastise their conduct, they will be receiving the attention they want and keep on the behaviour. Rather, work with a key expression, like ?Oops,? and then depart. Stay consistent with this particular along with your dog will soon learn he must keep all four paws on the ground to have your consideration.

To conclude, dogs really are a popular dog for folks. Pet dogs are lively, adorable, to make wonderful companions. When correctly qualified, puppies are excellent animals for anybody. In the event you keep in mind the advice out of this write-up, in that case your puppy will be properly qualified and a lovable partner to suit your needs.

In my site in spanish como educar a un perro how to training a dog, share information about training puppy and dogs or in spanish adiestramiento canino for more information please clic in before link.

Source: http://siscer.net/articles/pets/suggestions-for-simpler-training-your-dog/

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Thursday, July 19, 2012

Rock Climbing Destinations in San Diego County, California ...

Rock climbing is one of outdoor activities that locals and tourists love to do in San Diego, CA. There are many destinations for this activity and whether you go there for top roping or traditional climbing, you can do so at its different structures. These are the best areas for rock climbing in San Diego County as below.

Army Rock is one of the places recommended for climbing especially during the spring. It is composed of boulders of different heights and difficulty levels. You have the opportunity to try out the routes at a favorable day which are suited to your ability and skills when it comes to this sport.

The Culp Valley is a place where you can camp for the night but ground fires are not allowed. You can just bring your cheetah stun gun if you want to feel safe. There are many sections for climbing. Although they may differ on the levels of difficulty, they all provide a fun and great experience.

Carlsbad Boulders, just at the corner of the road in Palomar Airport, is also a suitable place for your climbing experience. You need to check out and follow the signs so that you will not be able to violate their rules and at the same time for your safety in your whole adventure.

Beirut is another climbing route in the county wherein you need to take a short and easy hike first before you will be able to access to the areas. You have to remember that you must not drive your car to the foot of the hill because it is not permitted.

Moreover, Dixon Lake is not only great for camping but it also has easy and not so complicated climbing areas which are most especially suited for top roping. You just need to bring all the gear needed or rent the suited equipment for the climb and you will have a great time.

Whether you are just a novice or an expert when it comes to this recreational activity, you can try out the routes at Mission Gorge. It is a best place for a trip especially during the summer. You must take note of the time when they will close the gates because if you wish to stay and camp you are not allowed anymore to get out and no one is allowed to enter as well.

Lastly, you must not fail to try out the climbing area at Mt. Woodson which is considered as one of the premier sites for this sport in the whole county. It is open all throughout the year. You must learn about the different routes or have someone to guide you through the area.

Tags: California, Recreation, Rock Climbing, San Diego, Sport

Source: http://www.southerncaliforniadirectory.com/blog/rock-climbing-destinations-in-san-diego-county-california/

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Source: http://nickylogan.typepad.com/blog/2012/07/rock-climbing-destinations-in-san-diego-county-california.html

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Source: http://mulvivymu.posterous.com/rock-climbing-destinations-in-san-diego-count

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Northern California comes to Charcut - 2012/07/17 11:49:33

On July 16, my husband and I had the pleasure of partaking in one heck of an event hosted by CHARCUT Roast House. Co-owners and chefs, John Jackson and Connie DeSousa, welcomed Michelin-Star chefs and friends, Hiro Sone and Lissa Doumani of California?s award-winning Terra (Napa Valley) and Ame Restaurant (San Francisco) to collaborate in their kitchen for a one-night-only, one-of-a-kind culinary event.

The six-course dinner with wine pairings began with milk-fed piglet and foie gras porchetta.
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Served chilled, the young pork was savoury and succulent. On the side was a salad of fris?e, fennel ribbons and an intense salsa verde aioli. For an extra bite of acidity, the salad was topped with crunchy-fried artichoke.

The wine pairing for our fresh starter was Thomas George Estates' magnificently clean 2009 Viognier from Catie?s Corner Vineyard in Sonoma?s Russian River Valley.

The second course put a spell on our table. Arriving in a simple, white bowl we were served what looked like soup, but turned out to be Chawan mushi, a traditional Japanese egg custard dish flavoured with dashi and mirin. Meticulously placed at the surface of the dish was the most tender and delicate sea urchin I?ve ever tasted. Paired with the subtly smoky dish was a simple and fresh 2009 Dry Creek Valley Sauvignon Musque from the vineyard of Brian and Janice Schmidt.

The third course definitely raised some eyebrows and instead of waiting to discuss it, Connie DeSousa jumped right in to tell the group about the Boudin Noir (blood sausage) with farm egg.

Made primarily of pig blood, pork, cream (and lots of it) and bread crumbs. DeSousa explained that she and co-chef John Jackson had been experimenting with cream to create a lighter blood sausage. Judging from the taste and weight of the thick, black sausage they were successful.

Plated in a skillet of home fried potatoes and perfectly cooked hard-boiled eggs, the breakfast inspired dish with Sylvan Star gouda was lovely with Thomas George Estate?s 2009 Chardonnay.

It?s hard to believe there was more, but stay with me. Our fourth course showcased broiled Alaskan Black Cod, and it was a savoury masterpiece.

Resting in a mouthwatering shiso?broth, the cod is beyond fresh and perfectly cooked ? but the broth, flavoured with ginger, garlic and mirin, really stole the show.

The Thomas George Estates 2009 Pinot Noir was the perfect pairing, a wine, as our host explained, where one of the key ingredients is Sonoma?s coastal fog.

The big, bad (as in good) dish of the night was the massive, rotisserie butcher board piled high with 12-hour smoked ribs, Brant Lake Wagyu butcher steaks and roasted marrowbones.

When the board came out, someone at our table cracked a joke about Brontosaurus ribs. Without a doubt, the Spring Creek Ranch ribs were big, tender and juicy. The twelve-hours of sweet, slow cooking was apparent. On the side, there were fresh yellow beans (with bacon of course, yum), tender slices of medium-rare Wagyu beef and CHARCUT?s trademark marrow served with Aviv Fried?s toasted bread.

The night ended on a high note with a sumptuous dessert of roasted apricot with almond cake, Noyau (fruit stone) ice cream and a cocktail of muddled strawberries and mint with brandy, amaretto and Chambord, finished with vanilla extract, ginger ale, lemon juice and honey syrup. The complex combination of flavours was a fitting end to a wonderful meal.

It was an honour and a privilege to be a part of such an impressive culinary event. Throughout the night, it was clear that the friendship between our hosts and the visiting chefs runs deep, and luckily for the diners in attendance, that friendship was expressed in every dish.

CHARCUT Roast House?
899 Centre Street SW, Calgary, Alberta
403-984-2180?

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Source: http://www.ffwdweekly.com/calgary-blogs/culture/2012/07/17/northern-california-comes-to-charcut-1103/

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The First Gay Military Wedding Couple Chats on Facebook

Will Umali-Behrens: Immediately following my divorce, I broke down and cried in the elevator. My lawyer said to me, "You are not divorcing your children, remember that." It was tough, because it was a huge part of your life. My number one concern was my children and also what was in store for Erwynn and me. We are both very strong people and just took one day at a time. Not only were we struggling with a divorce, but also struggling to fight to see our kids, protecting Erwynn's career and also maintaining our work jobs which are stressful just on their own. It was a very trying time for both of us. But it just brought us closer together!

Source: http://feeds.slate.com/click.phdo?i=e34120edeb024f0087c2eb7df5bddeb8

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Wednesday, July 18, 2012

Online-only: Christie's launches premier internet-exclusive wine ...

Auction house Christie?s is launching its first online-only premier internet-exclusive wine auction. Wine aficionados will find everything from ?82 Lafite and Latour at the high-end to hard-to-source California cult wines from Harlan Estate and Screaming Eagle.

Dubbed ?Signature Cellars?, the online-only auction is expected to attract bids as high as $35,000 for vintage fine wines. Signature Cellars is the first in a series of online-auctions which will run parallel to Christie?s traditional on-site auctions. Bidding for Christie?s new format auction opens August 6 and closes August 20.

?In keeping with our sentiment of something-for-everyone, there are also great rarities that will inspire any serious wine devotee looking to broaden their cellar, including pre and post-war vintages, magnums of fine Champagne and imperials of Classified Crus, top Ch?teauneuf-du-Pape in all formats, beautifully-aged rare Vintage Port, and a highly desirable swath of beloved Bandol wines from the legendary Domaine Tempier,? announced Christie?s.

In 2011, Christie?s held an online-only auction for a collection of Elizabeth Taylor jewels which fetched ?120.7 million in sales.

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Source: http://www.2luxury2.com/online-only-christies-launches-premier-internet-exclusive-wine-auction/

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You're selling your home, but are you in Selling Mode?

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As we live in our homes we adjust it to fit the rhythm of our lives.

This is? called Living Mode.

One of the biggest mistakes you can make is assuming that the perspective buyers will be able to see past your lifestyle and imagine themselves in your home. It is time to make changes so that the buyers can see your home's features.

This is called Selling Mode.

There are different guidelines for Selling Mode. The focus of your home has to change from you to the buyer's perspective as they walk through. After all, their perspective is their reality.

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Your Burlington?home has become a product and you need to highlight it's features for the buyer. Buyers are looking for space, natural light and storage.

Buyers need to see how big the bathrooms are not that your child is being potty trained.

Buyers want to see the condition of surfaces like counters, floors and tile. They don't need to see how old your tooth brush is or if you are running low on shampoo in the bath tub.

Buyers want to see if their furniture will fit in your rooms. To do this they will compare with your furniture. Set up conversational groupings and don't focus on the TV.

Buyers should remember the features of your home, not your collection.

Buyers want to see the storage space your home offers. Show them that the closets hold shoes, coats etc. Get rid of those shoe racks and trays by the front door.

Buyers will look inside your cupboards and appliances. You can no longer put off that cleaning.

Buyers want to see that you maintain your home. It's time to do all those repairs, small and large, that you have been putting off until later. Later it NOW.

It's time to shift gears into Selling Mode.

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Serving Burlington,Oakville, Milton, Hamilton & surrounding areas.???? 905-467-5353

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Source: http://activerain.com/blogsview/3378945/you-re-selling-your-home-but-are-you-in-selling-mode-

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Discovery Channel Superstar Is Grilling on a Shelf, Not a Grill [Image Cache]

Mike Rowe, we love your stuff on the Discovery Channel. Dirty Jobs! But one job that isn't dirty is being a grillmaster, when your grill is an imaginary grill that's actually a metal shelving unit in a Ford advertisement. Yum! More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/Pg05DbrdtkM/discovery-channel-superstar-is-grilling-on-a-shelf-not-a-grill

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Tuesday, July 17, 2012

Social Networking Online For Direct Sales Business | Build It Big ...


In any home party plan business social networking to find customers should be top priority.

People frequently throw around the term ?social networking? without really knowing what it is. Social networking is the use of any of the Internet sites that allow people to interact with each other. Social networking is not just Facebook or Twitter!

Blogs = Online Networking

social media marketing for home party businessBlog sites allow people to post their opinions on subjects and then encourage others to respond. Video hosting sites allow people to post their own videos and receive comments from viewers. These are both social networking activities that should be included in a home business..

Millions of people all over the world, and right in your backyard, use social networking sites to stay in touch with friends and find out about new companies. As part of your home party plan, you need to utilize social networking to find customers and generate interest in your parties.

YouTube & Video Hosting Websites

People network in YouTube and other video sites just like they do in Facebook.

The important thing to remember about social networking websites is that it does not cost anything to join them. You can reach people all over the world without paying a dime. That kind of marketing platform is powerful and something you should utilize to its fullest extent.

People love watching videos on the video hosting websites. You can start your own channel and use social networking to attract viewers. A home party plan can be significantly enhanced by product demonstration videos on the Internet. You can make your own videos and show people how your products work. You can also create videos aimed at getting potential party hosts interested in joining your organization.

Home Business Message Boards

Message boards, forums or Nings are also great ways to find new home business customers.

When you find message boards that deal with the products or services in your industry, then you have found a source for new customers. People will bring questions and comments to message boards to try and get input and answers from experts. You can act as that expert and help improve your status among the population on the message board. It can be a great way to reach out to new people and give new customers an idea of what you sell.

Blogging or Commenting For New Customers

Every party plan consultant should have a blog as their social networking anchor. Your blog is where you post information about upcoming parties and articles about your products. You can encourage people to ask questions by posting answers on your blog. Whenever you post on another social networking website, you should always have a link that points back to your blog.

Also, commenting on other home based business blogs or training sites in your niche with an attempt to add value and yet create curiosity will bring new customers to your site.

Top Social Networks For Home Business Online Networking

It seems like a new top social networking website comes along every couple of years that allows millions of people from all over the world to communicate.

The latest one being Pinterest. I have found Pinterest to be a very good format for bringing new people to my website. Party plan consultants can show off their products and meet new people in their niche.

Each social site is your chance to reach out to people who have similar interests and make them part of your customer network. Engage in conversations about your products and encourage customers to ask you questions on your social networking page. Post notifications of your new blog entries and use social networking to grow your business.

Every party plan consultant should have a social networking presence. Your business is social in nature, so it only makes sense that you would reach out to new customers using the existing networks of millions of people located all over the world.

Please comment.

Source: http://builditbigradioshow.com/direct-sales-tips/social-networking/

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Velocity Micro Vector Campus Edition (2012)


We all know that absolutely no one purchasing a computer for school would dare consider its prowess at anything other than strictly academic tasks. All that matters is a healthy processor and lots of memory?the very notion of also having a discrete video card capable of enhancing games (only after all the schoolwork is done, naturally) would never cross anyone?s mind. So we?re positive that most serious students will be scandalized by the 2012 revamp of the Velocity Micro Vector Campus Edition, which for $999 (direct) bridges the gap between those two worlds in a way that would do any teen or parent proud. So if you can see past your outrage at this fusion of gaming and processing prowess, you might just see an impressive everyday system. All this earns it our Editors' Choice for midrange desktops.

Design and Features
Like most Velocity Micro systems (such as the latest Raptor Z90 and last winter?s Vector Holiday Edition), this latest Vector Campus Edition uses a variation on the company?s classic MX2-W chassis: brushed-aluminum exterior, crisp edges, windowed side panel, and striking blue interior lighting. It?s a familiar look, but it?s one that quietly allures and one that works. The aesthetic doesn?t carry over to the included keyboard and mouse, alas?they?re both basic black plastic?but you can?t have everything.

On the component side, however, you can be forgiven for thinking you can. The Campus Edition is decently equipped with current midrange hardware that packs a punch without punching a hole in your budget. The processor is a 3.4GHz Intel Core i5-3570K, which has four processing cores but no Hyper-Threading support to give it control over eight simultaneous threads, but it?s been overclocked to a healthy 4.3GHz. A nice 8GB of RAM comes preinstalled, with two of the four RAM slots remaining free so you can add more down the line if you want. The video card uses the relatively powerful mainstream AMD Radeon HD 7750 chipset. You don?t get a ton of hard drive space?a mere 1TB?but there are two 3.5-inch bays free for future expansion. A DVD burner and multiformat card reader round out the external storage options.

Front-panel ports are fairly limited: the obligatory headphone and microphone, FireWire, and USB 2.0?unfortunately, no USB 3.0. You get a better selection on the rear panel, with two USB 3.0 ports, four USB 2.0 ports, eight-channel analog audio, PS/2, and Ethernet joining the DisplayPort, HDMI, and two DVI ports on the video card. USB dongles granting 802.11b/g/n Wi-Fi and Bluetooth 2.1 connectivity come pre-inserted as well.

One thing you don?t get: bloatware. Like most boutique manufacturers, Velocity Micro ships its systems clean, so when you boot into the 64-bit edition of Windows 7 Home Premium, you won?t find any clutter at all on your desktop. Open Office 3.4 and Microsoft Security Essentials are available as no-cost upgrades so you can also have basic productivity and malware-protection functionality right out of the box.

The Campus Edition is covered by a one-year parts-and-labor warranty, and an extra $69 gets you a one-year VelocityCare warranty that also includes on-site service.

Performance
Velocity Micro Campus Edition (2012)Regardless of why you need (or want) to use your system, the Campus Edition offers a compelling spread of performance across applications. It didn't nab the top spots in our Futuremark PCMark 7 all-around-system or CineBench R11.5 rendering tests?those went to the Acer Predator AG3620-UR21P (4,551 versus 4,041 and 7.52 versus 5.17 respectively). But the Campus Edition managed the lowest time in its class in both HandBrake (56 seconds, with the nearest competition the 1 minute 3 seconds of the Asus Essentio CM6870) and Adobe Photoshop CS5 (2 minutes 40 seconds, with the Acer Predator a close second with 2 minutes 47 seconds).

Velocity Micro Campus Edition (2012)

In gaming, the Campus Edition was almost as good: It was the champ at Futuremark 3DMark 11, in both the Entry (5,222) and Extreme (1,098) presets, and at 1,280-by-720-resolution Crysis with Medium graphical details (108 frames per second, or fps). The Alienware X51 ruled the roost with Lost Planet 2 at 1,280 by 720 and middle-quality graphics (86fps) and 35fps at 1,920 by 1,080 with high-quality graphics (the Campus Edition competed with 72fps and 28fps respectively); the Alienware also surpassed the Velocity Micro at Crysis at 1,920 by 1,080 with Very High details (22fps versus 21fps), but that's not exactly a crow-worthy victory).

Other systems out there might surpass the Velocity Micro Vector Campus Edition (2012) in certain areas?the Alienware X51 is slightly better at gaming, the Acer Predator AG3620-UR21P at some processing chores. But the Campus Edition earns its place as our new Editors? Choice for midrange desktops because of its strong commitment to balancing all the disciplines. It?s an ideal well-rounded desktop for pursuing your well-rounded education.

More Desktop reviews:
??? Acer Predator AG3620-UR21P
??? Velocity Micro Vector Campus Edition (2012)
??? Acer Aspire AM3970G-UW10P
??? Gateway DX4870-UR11P
??? Asus ET2701INKI-B046C
?? more

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/RLaIqpnfWrQ/0,2817,2406936,00.asp

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Kate Upton: "I'm Not Going to Starve Just to Be Thin"

On what planet is Kate Upton considered fat? The Sports Illustrated Swimsuit Issue cover girl, who practically breaks the Internet every time she dances on YouTube, is facing some criticism for her enviable body. Fortunately, she's not listening.

Source: http://www.ivillage.com/kate-upton-addresses-weight-critics/1-a-473223?dst=iv%3AiVillage%3Akate-upton-addresses-weight-critics-473223

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Monday, July 16, 2012

Genetically engineered bacteria prevent mosquitoes from transmitting malaria

Genetically engineered bacteria prevent mosquitoes from transmitting malaria [ Back to EurekAlert! ] Public release date: 16-Jul-2012
[ | E-mail | Share Share ]

Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health

Researchers at the Johns Hopkins Malaria Research Institute have genetically modified a bacterium commonly found in the mosquito's midgut and found that the parasite that causes malaria in people does not survive in mosquitoes carrying the modified bacterium. The bacterium, Pantoea agglomerans, was modified to secrete proteins toxic to the malaria parasite, but the toxins do not harm the mosquito or humans. According to a study published by PNAS, the modified bacteria were 98 percent effective in reducing the malaria parasite burden in mosquitoes.

"In the past, we worked to genetically modify the mosquito to resist malaria, but genetic modification of bacteria is a simpler approach," said Marcelo Jacobs-Lorena, PhD, senior author of the study and a professor with Johns Hopkins Bloomberg School of Public Health. "The ultimate goal is to completely prevent the mosquito from spreading the malaria parasite to people."

With the study, Jacobs-Lorena and his colleagues found that the engineered P. agglomerans strains inhibited development of the deadliest human malaria parasite Plasmodium falciparum and rodent malaria parasite Plasmodium berghei by up to 98 percent within the mosquito. The proportion of mosquitoes carrying parasites (prevalence) decreased by up to 84 percent.

"We demonstrate the use of an engineered symbiotic bacterium to interfere with the development of P. falciparum in the mosquito. These findings provide the foundation for the use of genetically modified symbiotic bacteria as a powerful tool to combat malaria," said Jacobs-Lorena.

Malaria kills more than 800,000 people worldwide each year. Many are children.

###

The authors of "Fighting malaria with engineered symbiotic bacteria from vector mosquitoes" are Sibao Wang, Anil K. Ghosh, Nicholas Bongio, Kevin A. Stebbings, David J. Lampe and Marcelo Jacobs-Lorena.

The research was supported by National Institute of Allergy and Infectious Diseases, the Bill & Melinda Gates Foundation, the Johns Hopkins Malaria Research Institute and the Bloomberg Family Foundation.

Follow the Johns Hopkins Bloomberg School of Public Health on Facebook at http://www.facebook.com/JohnsHopkinsSPH and Twitter at http://www.twitter.com/JohnsHopkinsSPH.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Genetically engineered bacteria prevent mosquitoes from transmitting malaria [ Back to EurekAlert! ] Public release date: 16-Jul-2012
[ | E-mail | Share Share ]

Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health

Researchers at the Johns Hopkins Malaria Research Institute have genetically modified a bacterium commonly found in the mosquito's midgut and found that the parasite that causes malaria in people does not survive in mosquitoes carrying the modified bacterium. The bacterium, Pantoea agglomerans, was modified to secrete proteins toxic to the malaria parasite, but the toxins do not harm the mosquito or humans. According to a study published by PNAS, the modified bacteria were 98 percent effective in reducing the malaria parasite burden in mosquitoes.

"In the past, we worked to genetically modify the mosquito to resist malaria, but genetic modification of bacteria is a simpler approach," said Marcelo Jacobs-Lorena, PhD, senior author of the study and a professor with Johns Hopkins Bloomberg School of Public Health. "The ultimate goal is to completely prevent the mosquito from spreading the malaria parasite to people."

With the study, Jacobs-Lorena and his colleagues found that the engineered P. agglomerans strains inhibited development of the deadliest human malaria parasite Plasmodium falciparum and rodent malaria parasite Plasmodium berghei by up to 98 percent within the mosquito. The proportion of mosquitoes carrying parasites (prevalence) decreased by up to 84 percent.

"We demonstrate the use of an engineered symbiotic bacterium to interfere with the development of P. falciparum in the mosquito. These findings provide the foundation for the use of genetically modified symbiotic bacteria as a powerful tool to combat malaria," said Jacobs-Lorena.

Malaria kills more than 800,000 people worldwide each year. Many are children.

###

The authors of "Fighting malaria with engineered symbiotic bacteria from vector mosquitoes" are Sibao Wang, Anil K. Ghosh, Nicholas Bongio, Kevin A. Stebbings, David J. Lampe and Marcelo Jacobs-Lorena.

The research was supported by National Institute of Allergy and Infectious Diseases, the Bill & Melinda Gates Foundation, the Johns Hopkins Malaria Research Institute and the Bloomberg Family Foundation.

Follow the Johns Hopkins Bloomberg School of Public Health on Facebook at http://www.facebook.com/JohnsHopkinsSPH and Twitter at http://www.twitter.com/JohnsHopkinsSPH.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-07/jhub-geb071312.php

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